SPTN2 rabbit pAb

SKU: ES12970

Size: 100μL

Source:Rabbit

Applications:WB;IHC

Reactivity:Human;Rat

Dilution:WB 1:500-2000;IHC-p 1:50-300

Immunogen:Synthesized peptide derived from human SPTN2 AA range: 644-694

Storage_stability:-20°C/1 year

Clonality:Polyclonal

Isotype:IgG

Concentration:1 mg/ml

Observed_band(KD):

Human_gene_id:6712

Human_swiss_prot_no:O15020

Subcellular_location:Cytoplasm, cytoskeleton. Cytoplasm, cell cortex.

Other_name:

Background:Spectrins are principle components of a cell's membrane-cytoskeleton and are composed of two alpha and two beta spectrin subunits. The protein encoded by this gene (SPTBN2), is called spectrin beta non-erythrocytic 2 or beta-III spectrin. It is related to, but distinct from, the beta-II spectrin gene which is also known as spectrin beta non-erythrocytic 1 (SPTBN1). SPTBN2 regulates the glutamate signaling pathway by stabilizing the glutamate transporter EAAT4 at the surface of the plasma membrane. Mutations in this gene cause a form of spinocerebellar ataxia, SCA5, that is characterized by neurodegeneration, progressive locomotor incoordination, dysarthria, and uncoordinated eye movements. [provided by RefSeq, Dec 2009],