SPOP Antibody, HRP conjugated - Cat. #: CSB-PA022601LB01HU

SKU: CSB-PA022601LB01HU

Size :50ug

Clone Number:

Aliases:BTBD32 antibody; HIB homolog 1 antibody; Roadkill homolog 1 antibody; Speckle type POZ protein antibody; Speckle-type POZ protein antibody; SPOP antibody; SPOP_HUMAN antibody; TEF 2 antibody; TEF2 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:O43791

Immunogen:Recombinant Human Speckle-type POZ protein (48-374AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA

Background:Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. In complex with CUL3, involved in ubiquitination and proteasomal degradation of BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3. In complex with CUL3, involved in ubiquitination of H2AFY and BMI1; this does not lead to their proteasomal degradation. Inhibits transcriptional activation of PDX1/IPF1 targets, such as insulin, by promoting PDX1/IPF1 degradation. The cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex containing homodimeric SPOP has higher ubiquitin ligase activity than the complex that contains the heterodimer formed by SPOP and SPOPL.

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:HRP

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:SPOP

Research Areas:Epigenetics and Nuclear Signaling