SP100 Antibody - Cat. #: CSB-PA102856

SKU: CSB-PA102856

Size :100ul

Clone Number:

Aliases:DKFZp686E07254 antibody; FLJ00340 antibody; FLJ34579 antibody; Lysp100b antibody; Nuclear antigen Sp100 antibody; Nuclear autoantigen Sp 100 antibody; Nuclear autoantigen Sp-100 antibody; Nuclear autoantigen Sp100 antibody; Nuclear dot associated Sp100 protein antibody; Nuclear dot-associated Sp100 protein antibody; SP 100 antibody; SP100 antibody; SP100 HMG nuclear autoantigen antibody; SP100 nuclear antigen antibody; SP100_HUMAN antibody; Speckled 100 kDa antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:P23497

Immunogen:Synthesized peptide derived from Internal of Human SP100.

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA, WB; WB:1:500-1:3000

Background:Together with PML, this tumor suppressor is a major constituent of the PML bodies, a subnuclear organelle involved in a large number of physiological processes including cell growth, differentiation and apoptosis. Functions as a transcriptional coactivator of ETS1 and ETS2 according to . Under certain conditions, it may also act as a corepressor of ETS1 preventing its binding to DNA according to . Through the regulation of ETS1 it may play a role in angiogenesis, controlling endothelial cell motility and invasion. Through interaction with the MRN complex it may be involved in the regulation of telomeres lengthening. May also regulate TP53-mediated transcription and through CASP8AP2, regulate FAS-mediated apoptosis. Also plays a role in infection by viruses, including human cytomegalovirus and Epstein-Barr virus, through mechanisms that may involve chromatin and/or transcriptional regulation.

Dent A.L., Blood 88:1423-1426(1996).
Seeler J.-S., Proc. Natl. Acad. Sci. U.S.A. 95:7316-7321(1998).
Szostecki C., J. Immunol. 145:4338-4347(1990).

Clonality:Polyclonal

Isotype:IgG

Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Conjugate:Non-conjugated

Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form:liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:SP100

Research Areas:Epigenetics and Nuclear Signaling;Tags & Cell Markers?Immunology