SOD1 rabbit pAb

SKU: ES20629

Size: 100μL

Source:Rabbit

Applications:WB;IHC;IF

Reactivity:Human;Mouse;Rat

Dilution:Western Blot: 1/500 - 1/2000.IHC-p:1:50-300. Not yet tested in other applications.

Immunogen:Synthesized peptide derived from the Internal region of human SOD-1.

Storage_stability:-20°C/1 year

Clonality:Polyclonal

Isotype:IgG

Concentration:

Observed_band(KD):18kD

Human_gene_id:6647

Human_swiss_prot_no:P00441

Subcellular_location:Cytoplasm . Mitochondrion . Nucleus . Predominantly cytoplasmic; the pathogenic variants ALS1 Arg-86 and Ala-94 gradually aggregates and accumulates in mitochondria. .

Other_name:SOD1; Superoxide dismutase [Cu-Zn]; Superoxide dismutase 1; hSod1

Background:The protein encoded by this gene binds copper and zinc ions and is one of two isozymes responsible for destroying free superoxide radicals in the body. The encoded isozyme is a soluble cytoplasmic protein, acting as a homodimer to convert naturally-occuring but harmful superoxide radicals to molecular oxygen and hydrogen peroxide. The other isozyme is a mitochondrial protein. Mutations in this gene have been implicated as causes of familial amyotrophic lateral sclerosis. Rare transcript variants have been reported for this gene. [provided by RefSeq, Jul 2008],