Socs3 Antibody, Biotin conjugated - Cat. #: CSB-PA022392LD01RA

SKU: CSB-PA022392LD01RA

Size :50ug

Clone Number:

Aliases:Socs3 antibody; Cish3Suppressor of cytokine signaling 3 antibody; SOCS-3 antibody; Cytokine-inducible SH2 protein 3 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Rattus norvegicus (Rat)

UniProt ID:O88583

Immunogen:Recombinant Rat Suppressor of cytokine signaling 3 protein (1-225AA)

Raised in:Rabbit

Species Reactivity:Rat

Tested Applications:ELISA

Background:SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity. Suppresses fetal liver erythropoiesis. Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells. Regulates IL-6 signaling in vivo. Probable substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize IL6ST (By similarity).

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:Biotin

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:Socs3

Research Areas:Epigenetics and Nuclear Signaling; Cancer; Immunology; Metabolism; Signal transduction; Stem cells