SNAI1 Monoclonal Antibody

SKU: BT-MCA4792

Size:100μL

Background:Snail is a zinc-finger transcription factor that can repress E-cadherin transcription. Downregulation of E-cadherin is associated with epithelial-mesenchymal transition during embryonic development, a process also exploited by invasive cancer cells . Indeed, loss of E-cadherin expression is correlated with the invasive properties of some tumors and there is a considerable inverse correlation between Snail and E-cadherin mRNA levels in epithelial tumor cell lines . In addition, Snail blocks the cell cycle and confers resistance to cell death . Phosphorylation of Snail by GSK-3 and PAK1 regulates its stability, cellular localization and function .Tissue specificity: Expressed in a variety of tissues with the highest expression in kidney.

Research_area:Epigenetics and Nuclear Signaling

Target_protein:SNAI1

applications:

Reactivity:Human

Clonality:Monoclonal

Clone ID:6D2

Host:Mouse

Isotype:Mouse IgG1

Gene Symbol/ Name:SNAI1

Immunogen:Purified recombinant fragment of human SNAI1 expressed in E. Coli.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Ascitic fluid containing 0.03% sodium azide.

Concentration:

Molecular weight(Da):29kDa

UniProt accession:O95863

Synonyms:SNA, SNAH, SLUGH2, dJ710H13.1, SNAI1

GeneID:6615