SMG8 Polyclonal Antibody

SKU: E-AB-12757

Size::120μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Polyclonal Antibodies

Abbreviation:SMG8

Target Synonym:ABC 2;ABC2;Amplified in breast cancer gene 2 protein;Chromosome 17 open reading;chromosome 17 open reading frame 71;FLJ10587;Protein smg 8 homolog;protein SMG8;SMG8;SMG8 protein

Research Areas:Cancer

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human;Mouse

Application:IHC

Isotype:IgG

Clonality:Polyclonal

Clone NO.:

UNIProt ID:Q8ND04

Accession:

Background:Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited by release factors to stalled ribosomes together with SMG1 and SMG9 (forming the SMG1C protein kinase complex) and, in the SMG1C complex, is required to mediate the recruitment of SMG1 to the ribosome:SURF complex and to suppress SMG1 kinase activity until the ribosome:SURF complex locates the exon junction complex (EJC). Acts as a regulator of kinase activity.

Concentration:0.3 mg/mL

Immunogen:Synthetic peptide of human SMG8

Buffer:PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Purification method:Affinity purification

Dilution:IHC 1:25-1:100

Calculated MW:

ObservedMW: