SMC1(Phospho Ser966) Polyclonal Antibody

SKU: BT-AP08000

Size:100μL

Background:Proper cohesion of sister chromatids is a prerequisite for the correct segregation of chromosomes during cell division. The cohesin multiprotein complex is required for sister chromatid cohesion. This complex is composed partly of two structural maintenance of chromosomes (SMC) proteins| SMC3 and either SMC1B or the protein encoded by this gene. Most of the cohesin complexes dissociate from the chromosomes before mitosis| although those complexes at the kinetochore remain. Therefore| the encoded protein is thought to be an important part of functional kinetochores. In addition| this protein interacts with BRCA1 and is phosphorylated by ATM| indicating a potential role for this protein in DNA repair. This gene| which belongs to the SMC gene family| is located in an area of the X-chromosome that escapes X inactivation. Mutations in this gene result in Cornelia de Lange syndrome. Altern

Research_area:Epigenetics and nuclear signaling; Cell biology

Target_protein:SMC1A

applications:WB, IHC-p, IF, ELISA

Reactivity:Human, Mouse, Rat

Clonality:Polyclonal

Clone ID:

Host:Rabbit

Isotype:IgG

Gene Symbol/ Name:Structural maintenance of chromosomes protein 1A

Immunogen:The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage:-20°C for 1 year

Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration:1 mg/ml

Molecular weight(Da):143233

UniProt accession:Human: Q14683; Mouse: Q9CU62; Rat: Q9Z1M9

Synonyms:Structural maintenance of chromosomes protein 1A; SMC1A; DXS423E; KIAA0178; SB1.8; SMC1; SMC1L1; Structural maintenance of chromosomes protein 1A; SMC protein 1A; SMC-1-alpha; SMC-1A; Sb1.8

GeneID:Human: 8243; Mouse: 24061; Rat: 63996