SMARCA2 Antibody, FITC conjugated - Cat. #: CSB-PA021799LC01HU

SKU: CSB-PA021799LC01HU

Size :50ug

Clone Number:

Aliases:ATP dependent helicase SMARCA2 antibody; ATP-dependent helicase SMARCA2 antibody; BAF190 antibody; BAF190B antibody; BRG1-associated factor 190B antibody; BRM antibody; FLJ36757 antibody; Global transcription activator homologous sequence antibody; hBRM antibody; hSNF2a antibody; MGC74511 antibody; Possible global transcription activator SNF2L2 antibody; Probable global transcription activator SNF2L2 antibody; Protein brahma homolog antibody; SMARCA2 antibody; SMCA2_HUMAN antibody; SNF2 alpha antibody; SNF2 like 2 antibody; SNF2-alpha antibody; SNF2/SWI2 like protein 2 antibody; SNF2L2 antibody; SNF2LA antibody; Sth1p antibody; Sucrose nonfermenting 2 like protein 2 antibody; SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily A member 2 antibody; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:P51531

Immunogen:Recombinant Human Probable global transcription activator SNF2L2 protein (700-1216AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:

Background:Transcriptional coactivator cooperating with nuclear hormone receptors to potentiate transcriptional activation. Also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth.

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:FITC

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:SMARCA2

Research Areas:Epigenetics and Nuclear Signaling