SLC5A8 Antibody, Biotin conjugated - Cat. #: CSB-PA836676LD01HU

SKU: CSB-PA836676LD01HU

Size :50ug

Clone Number:

Aliases:AIT antibody; Apical iodide transporter antibody; Electrogenic sodium monocarboxylate cotransporter antibody; MGC125354 antibody; SC5A8_HUMAN antibody; SLC5A8 antibody; SMCT antibody; SMCT1 antibody; sodium coupled monocarboxylate transporter 1 antibody; Sodium iodide related cotransporter antibody; Sodium iodide-related cotransporter antibody; Sodium-coupled monocarboxylate transporter 1 antibody; solute carrier family 5 iodide transporter member 8 antibody; Solute carrier family 5 member 8 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q8N695

Immunogen:Recombinant Human Sodium-coupled monocarboxylate transporter 1 protein (540-610AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA

Background:Acts as an electrogenic sodium (Na(+)) and chloride (Cl-)-dependent sodium-coupled solute transporter, including transport of monocarboxylates (short-chain fatty acids including L-lactate, D-lactate, pyruvate, acetate, propionate, valerate and butyrate), lactate, mocarboxylate drugs (nicotinate, benzoate, salicylate and 5-aminosalicylate) and ketone bodies (beta-D-hydroxybutyrate, acetoacetate and alpha-ketoisocaproate), with a Na(+):substrate stoichiometry of between 4:1 and 2:1. Catalyzes passive carrier mediated diffusion of iodide. Mediates iodide transport from the thyrocyte into the colloid lumen through the apical membrane. May be responsible for the absorption of D-lactate and monocarboxylate drugs from the intestinal tract. Acts as a tumor suppressor, suppressing colony formation in colon cancer, prostate cancer and glioma cell lines. May play a critical role in the entry of L-lactate and ketone bodies into neurons by a process driven by an electrochemical Na(+) gradient and hence contribute to the maintenance of the energy status and function of neurons.

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:Biotin

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:SLC5A8

Research Areas:Neuroscience; Cancer; Cell biology; Metabolism; Signal transduction