SKP2 Antibody, FITC conjugated - Cat. #: CSB-PA613392LC01HU

SKU: CSB-PA613392LC01HU

Size :50ug

Clone Number:

Aliases:CDK2/Cyclin A associated protein p45 antibody; Cyclin A/CDK2 associated protein p45 antibody; Cyclin-A/CDK2-associated protein p45 antibody; F box protein Skp2 antibody; F box/LRR repeat protein 1 antibody; F-box protein Skp2 antibody; F-box/LRR-repeat protein 1 antibody; FBL 1 antibody; FBL1 antibody; FBXL 1 antibody; FBXL1 antibody; FLB 1 antibody; FLB1 antibody; MGC1366 antibody; p45 antibody; p45skp2 antibody; S phase kinase associated protein 2 (p45) antibody; S phase kinase associated protein 2 antibody; S-phase kinase-associated protein 2 antibody; S-phase kinase-associated protein 2 E3 ubiquitin protein ligase antibody; SKP 2 antibody; Skp2 antibody; SKP2_HUMAN antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q13309

Immunogen:Recombinant Human S-phase kinase-associated protein 2 protein (1-424AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:

Background:Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. Specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. Degradation of CDKN1B/p27kip also requires CKS1. Recognizes target proteins ORC1, CDT1, RBL2, KMT2A/MLL1, CDK9, RAG2, FOXO1, UBP43, and probably MYC, TOB1 and TAL1. Degradation of TAL1 also requires STUB1. Recognizes CDKN1A in association with CCNE1 or CCNE2 and CDK2. Promotes ubiquitination and destruction of CDH1 in a CK1-Dependent Manner, thereby regulating cell migration.

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:FITC

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:SKP2

Research Areas:Cancer; Cardiovascular; Cell biology