SIGMAR1 Antibody - Cat. #: CSB-PA021320LA01HU

SKU: CSB-PA021320LA01HU

Size :50ug

Clone Number:

Aliases:Aging associated gene 8 protein antibody; Aging-associated gene 8 protein antibody; AL024364 antibody; hSigmaR1 antibody; mSigmaR1 antibody; opioid receptor, sigma 1 antibody; opioid receptor, sigma 1 isoform 1 antibody; RP23 167I12.6 antibody; SGMR1_HUMAN antibody; SIG 1R antibody; SIG-1R antibody; Sigma 1-type opioid receptor antibody; Sigma non-opioid intracellular receptor 1 antibody; sigma1 receptor antibody; Sigma1-receptor antibody; Sigma1R antibody; Sigmar1 antibody; SR BP antibody; SR-BP antibody; SR31747 binding protein antibody; SR31747-binding protein antibody; SRBP antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q99720

Immunogen:Recombinant Human Sigma non-opioid intracellular receptor 1 protein (112-169AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA, IHC; Recommended dilution: IHC:1:20-1:200

Background:Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Involved in the regulation of different receptors it plays a role in BDNF signaling and EGF signaling. Also regulates ion channels like the potassium channel and could modulate neurotransmitter release. Plays a role in calcium signaling through modulation together with ANK2 of the ITP3R-dependent calcium efflux at the endoplasmic reticulum. Plays a role in several other cell functions including proliferation, survival and death. Originally identified for its ability to bind various psychoactive drugs it is involved in learning processes, memory and mood alteration (PubMed:16472803, PubMed:9341151). Necessary for proper mitochondrial axonal transport in motor neurons, in particular the retrograde movement of mitochondria (By similarity).

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:Non-conjugated

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:SIGMAR1

Research Areas:Others