SH-PTP2 Polyclonal Antibody

SKU: E-AB-14341

Size: 200μL

Storage: Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping: The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.

Exp date: 12 months

Category ID_II: Primary Antibodies

Category ID_III: Polyclonal Antibodies

Abbreviation: PTPN11

Target Synonym: BPTP3;CFC;JMML;METCDS;MGC14433;NS1;OTTHUMP00000166107;OTTHUMP00000166108;Protein tyrosine phosphatase 2;Protein tyrosine phosphatase 2C;Protein tyrosine phosphatase non receptor type 11;Protein-tyrosine phosphatase 1D;Protein-tyrosine phosphatase 2C;PTN11;PTP-1D;PTP-2C;PTP1D;PTP2C;PTPN11;SAP2;SH-PTP2;SH-PTP3;SH2 domain containing protein tyrosine phosphatase 2;SHP 2;SHP-2;Shp2;SHPTP2;SHPTP3;Syp;Tyrosine-protein phosphatase non-receptor type 11

Research Areas: Cancer;Neuroscience;Signal Transduction

Conjugation: Unconjugated

Host: Rabbit

Species reactivity: Human;Mouse;Rat

Application: WB

Isotype: IgG

Clonality: Polyclonal

Clone NO.:

UNIProt ID: Q06124

Accession:

Background: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. Two transcript variants encoding different isoforms have been found for this gene.

Concentration: 0.3 mg/mL

Immunogen: Recombinant protein of human PTPN11

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Purification method: Affinity purification

Dilution: WB 1:200-1:1000

Calculated MW: 68kDa

ObservedMW: