SGMS1 Antibody, FITC conjugated - Cat. #: CSB-PA801243LC01HU

SKU: CSB-PA801243LC01HU

Size :50ug

Clone Number:

Aliases:SGMS1 antibody; MOB antibody; SMS1 antibody; TMEM23 antibody; Phosphatidylcholine:ceramide cholinephosphotransferase 1 antibody; EC 2.7.8.27 antibody; Medulla oblongata-derived protein antibody; Protein Mob antibody; Sphingomyelin synthase 1 antibody; Transmembrane protein 23 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q86VZ5

Immunogen:Recombinant Human Phosphatidylcholine:ceramide cholinephosphotransferase 1 protein (48-137AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:

Background:Sphingomyelin synthases synthesize the sphingolipid, sphingomyelin, through transfer of the phosphatidyl head group, phosphatidylcholine, on to the primary hydroxyl of ceramide. The reaction is bidirectional depending on the respective levels of the sphingolipid and ceramide. Golgi apparatus SMS1 directly and specifically recognizes the choline head group on the substrate, requiring two fatty chains on the choline-P donor molecule in order to be recognized efficiently as a substrate. Major form in macrophages. Required for cell growth in certain cell types such as HeLa cells. Suppresses BAX-mediated apoptosis and also prevents cell death in response to stimuli such as hydrogen peroxide, osmotic stress, elevated temperature and exogenously supplied sphingolipids. May protect against cell death by reversing the stress-inducible increase in levels of proapoptotic ceramide.

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:FITC

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:SGMS1

Research Areas:Cancer; Metabolism; Signal transduction