SETD7/SET7/9 Monoclonal Antibody

SKU: AN200053P

Size::

Storage:This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Monoclonal Antibodies

Abbreviation:SETD7

Target Synonym:KMT;SETD;KIAA;SET;SETD7;KMT7;SET7;SET7/9;SET9;KIAA1717

Research Areas:Epigenetics and Nuclear Signaling

Conjugation:Unconjugated

Host:Mouse

Species reactivity:Human

Application:WB

Isotype:IgG1

Clonality:Monoclonal

Clone NO.:12F11

UNIProt ID:Q8WTS6

Accession:

Background:Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP50-mediated transcriptional activation.

Concentration:1 mg/mL

Immunogen:Recombinant Human SETD7 / SET7 / 9 protein

Buffer:0.2 μm filtered solution in PBS

Purification method:Protein A

Dilution:WB 1:500-1:1000;

Calculated MW:41 kDa

ObservedMW:53 kDa