RRP8 Antibody - Cat. #: CSB-PA249711

SKU: CSB-PA249711

Size :100ul

Clone Number:

Aliases:Cerebral protein 1 antibody; hypothetical protein LOC23378 antibody; KIAA0409 antibody; NML antibody; Nucleomethylin antibody; Ribosomal RNA processing 8 methyltransferase homolog antibody; Ribosomal RNA processing 8, methyltransferase, homolog (yeast) antibody; Ribosomal RNA processing protein 8 antibody; Ribosomal RNA-processing protein 8 antibody; RRP 8 antibody; RRP8 antibody; RRP8 methyltransferase homolog antibody; RRP8_HUMAN antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:O43159

Immunogen:Synthesized peptide derived from internal of Human HUCE1.

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA, WB; WB:1:500-1:3000

Background:Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD+/NADP+ ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown.

Yazaki M., Submitted (AUG-1996) to the EMBL/GenBank/DDBJ databases.
Ishikawa K., DNA Res. 4:307-313(1997).
The MGC Project Team; Genome Res. 14:2121-2127(2004).

Clonality:Polyclonal

Isotype:IgG

Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Conjugate:Non-conjugated

Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form:liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:RRP8

Research Areas:Cell biology