RNF128 Antibody, Biotin conjugated - Cat. #: CSB-PA837448LD01HU

SKU: CSB-PA837448LD01HU

Size :50ug

Clone Number:

Aliases:E3 ubiquitin protein ligase RNF128 antibody; E3 ubiquitin-protein ligase RNF128 antibody; FLJ23516 antibody; Gene related to anergy in lymphocytes protein antibody; GRAIL antibody; RING finger protein 128 antibody; RN128_HUMAN antibody; RNF128 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q8TEB7

Immunogen:Recombinant Human E3 ubiquitin-protein ligase RNF128 protein (229-400AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA

Background:E3 ubiquitin-protein ligase that catalyzes \'Lys-48\'- and \'Lys-63\'-linked polyubiquitin chains formation. Functions as an inhibitor of cytokine gene transcription. Inhibits IL2 and IL4 transcription, thereby playing an important role in the induction of the anergic phenotype, a long-term stable state of T-lymphocyte unresponsiveness to antigenic stimulation associated with the blockade of interleukin production. Ubiquitinates ARPC5 with \'Lys-48\' linkages and COR1A with \'Lys-63\' linkages leading to their degradation, down-regulation of these cytosleletal components results in impaired lamellipodium formation and reduced accumulation of F-actin at the immunological synapse. Functions in the patterning of the dorsal ectoderm; sensitizes ectoderm to respond to neural-inducing signals.

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:Biotin

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:RNF128

Research Areas:Cell biology