RNASEL Antibody, Biotin conjugated - Cat. #: CSB-PA313223LD01HU

SKU: CSB-PA313223LD01HU

Size :50ug

Clone Number:

Aliases:2 5A dependent ribonuclease antibody; 2 5A dependent RNase antibody; 2' 5' oligoisoadenylate synthetase dependent antibody; 2-5A-dependent ribonuclease antibody; 2-5A-dependent RNase antibody; DKFZp781D08126 antibody; Interferon induced 2 5A dependent RNase antibody; MGC104972 antibody; MGC133329 antibody; PRCA 1 antibody; PRCA1 antibody; Ribonuclease 4 antibody; Ribonuclease L (2' 5' oligoisoadenylate synthetase dependent) antibody; Ribonuclease L antibody; Ribonuclease4 antibody; RibonucleaseL antibody; RN5A_HUMAN antibody; RNase L antibody; Rnasel antibody; RNS 4 antibody; RNS4 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q05823

Immunogen:Recombinant Human 2-5A-dependent ribonuclease protein (330-741AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA

Background:Endoribonuclease that functions in the interferon (IFN) antiviral response. In INF treated and virus infected cells, RNASEL probably mediates its antiviral effects through a combination of direct cleavage of single-stranded viral RNAs, inhibition of protein synthesis through the degradation of rRNA, induction of apoptosis, and induction of other antiviral genes. RNASEL mediated apoptosis is the result of a JNK-dependent stress-response pathway leading to cytochrome c release from mitochondria and caspase-dependent apoptosis. Therefore, activation of RNASEL could lead to elimination of virus infected cells under some circumstances. Might play a central role in the regulation of mRNA turnover.

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:Biotin

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:RNASEL

Research Areas:Epigenetics and Nuclear Signaling; Immunology