RIPK1 Polyclonal Antibody

SKU: E-AB-18284

Size: 200μL

Storage: Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping: The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.

Exp date: 12 months

Category ID_II: Primary Antibodies

Category ID_III: Polyclonal Antibodies

Abbreviation: RIPK1

Target Synonym: Cell death protein RIP;FLJ39204;OTTHUMP00000039163;Receptor (TNFRSF) interacting serine threonine kinase 1;receptor interacting protein 1;Receptor interacting protein;Receptor interacting protein kinase 1;Receptor interacting serine threonine protein kinase 1;Receptor TNFRSF interacting serine threonine kinase 1;Receptor-interacting protein 1;Receptor-interacting serine/threonine-protein kinase 1;Rinp;RIP 1;RIP;Rip-1;RIP1;RIPK 1;Ripk1;RIPK1;Serine threonine protein kinase RIP;Serine/threonine-protein kinase RIP

Research Areas: Cancer;Cell Biology;Signal transduction

Conjugation: Unconjugated

Host: Rabbit

Species reactivity: Human

Application: WB;IHC

Isotype: IgG

Clonality: Polyclonal

Clone NO.:

UNIProt ID: Q13546

Accession:

Background: Serine-threonine kinase which transduces inflammatory and cell-death signals (programmed necrosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage. Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor. Phosphorylates DAB2IP at 'Ser-728' in a TNF-alpha-dependent manner, and thereby activates the MAP3K5-JNK apoptotic cascade. Ubiquitination by TRAF2 via 'Lys-63'-link chains acts as a critical enhancer of communication with downstream signal transducers in the mitogen-activated protein kinase pathway and the NF-kappa-B pathway, which in turn mediate downstream events including the activation of genes encoding inflammatory molecules. Polyubiquitinated protein binds to IKBKG/NEMO, the regulatory subunit of the IKK complex, a critical event for NF-kappa-B activation. Interaction with other cellular RHIM-containing adapters initiates gene activation and cell death. RIPK1 and RIPK3 association, in particular, forms a necrosis-inducing complex.

Concentration: 0.7 mg/mL

Immunogen: Fusion protein of human RIPK1

Buffer: PBS with 0.05% NaN3 and 40% Glycerol,pH7.4

Purification method: Antigen affinity purification

Dilution: WB 1:500-1:2000;IHC 1:50-1:300

Calculated MW: 76 kDa

ObservedMW: Refer to figures