RGMA Antibody, HRP conjugated - Cat. #: CSB-PA836186LB01HU

SKU: CSB-PA836186LB01HU

Size :50ug

Clone Number:

Aliases:Repulsive guidance molecule A antibody; RGM antibody; RGM domain family member A antibody; RGMA antibody; RGMA_HUMAN antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q96B86

Immunogen:Recombinant Human Repulsive guidance molecule A protein (153-408AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA

Background:Member of the repulsive guidance molecule (RGM) family that performs several functions in the developing and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of RHOA-ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG-PTK2/FAK1 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1/neogenin leads to HRAS inactivation by influencing HRAS-PTK2/FAK1-AKT1 pathway. It also functions as a bone morphogenetic protein (BMP) coreceptor that may signal through SMAD1, SMAD5, and SMAD8.

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:HRP

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:RGMA

Research Areas:Neuroscience; Stem cells