REST antibody , Cat. # FNab07244

SKU: FNab07244

Size:100ug

Purification:Immunogen affinity purified

Form:liquid

Purity:?95% as determined by SDS-PAGE

Host:Rabbit

Clonality:polyclonal

Clone ID:

Isotype:IgG

Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.)

Background:Transcriptional repressor which binds neuron-restrictive silencer element(NRSE) and represses neuronal gene transcription in non-neuronal cells. Restricts the expression of neuronal genes by associating with two distinct corepressors, mSin3 and CoREST, which in turn recruit histone deacetylase to the promoters of REST-regulated genes. Mediates repression by recruiting the BHC complex at RE1/NRSE sites which acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. Transcriptional repression by REST-CDYL via the recruitment of histone methyltransferase EHMT2 may be important in transformation suppression.

Immunogen:RE1-silencing transcription factor

Synonyms:NRSF, REST, X2 box repressor, XBR

Observed MW:122 kDa, 200kd

Uniprot ID:Q13127

Reactivity:Human, Rat

Tested Application:ELISA, WB, IP

Recommended dilution:WB: 1:500-1:1000; IP: 1:500-1:2000

Gene ID:5978

Research Area:Stem Cells, Metabolism