REST Antibody - Cat. #: CSB-PA049156

SKU: CSB-PA049156

Size :100ul

Clone Number:

Aliases:Neural Restrictive Silencer Factor antibody; Neural-restrictive silencer factor antibody; Neuron Restrictive Silencer Factor antibody; NRSF antibody; RE1 silencing transcription factor antibody; RE1-silencing transcription factor antibody; Repressor binding to the X2 box antibody; rest antibody; REST protein antibody; REST_HUMAN antibody; X2 box repressor antibody; XBR antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q13127

Immunogen:Peptide sequence around aa.873~877(R-E-E-A-S) derived from Human REST.

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA, WB; WB:1:500-1:1000

Background:Transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells. Restricts the expression of neuronal genes by associating with two distinct corepressors, mSin3 and CoREST, which in turn recruit histone deacetylase to the promoters of REST-regulated genes. Mediates repression by recruiting the BHC complex at RE1/NRSE sites which acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier.

Chong J.A.et.al. (1995)Cell 80:949-957
Schoenherr C.J.et.al.(1995)Science 267:1360-1363
Scholl T.et.al.(1996)J. Immunol. 156:1448-1457
Lunyak V.V.et.al. (2002)Science 298:1747-1752

Clonality:Polyclonal

Isotype:IgG

Purification Method:Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Conjugate:Non-conjugated

Buffer:Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form:liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:REST

Research Areas:Epigenetics and Nuclear Signaling?Neuroscience