Recombinant TSPAN1 Monoclonal Antibody

SKU: AN300264P

Size::

Storage:This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Recombinant Antibodies

Abbreviation:TSPAN1

Target Synonym:NET;TSPAN;TM4C;TM4SF;NET1;TSPAN1

Research Areas:Signal Transduction;Cell Biology;Cancer

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human

Application:IHC-P;FCM

Isotype:IgG

Clonality:Rabbit Monoclonal

Clone NO.:11B6

UNIProt ID:O60635

Accession:

Background:TSPAN1 belongs to the transmembrane 4 superfamily, also known as the tetraspanin family. Tetraspanins have four hydrophobic domains, intracellular N- and C-termini and two extracellular domains. Tetraspanins act as scaffolding proteins, anchoring multiple proteins to one area of the cell membrane. They also mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. TSPAN1 interacts with human thiamine transporter-1 (hTHTR-1). HTHTR-1 contributes to intestinal thiamine uptake, and its function is regulated at both the transcriptional and posttranscriptional levels. TSPAN1 and hTHTR-1 colocalize in human intestinal epithelial HuTu-8 cells. Coexpression of TSPAN1 in these cells led to a significant decrease in the rate of degradation of hTHTR-1 compared with cells expressing the hTHTR-1 alone; in fact the half-life of the TSPAN1 protein was twice longer in the former cell type compared with the latter cell type.

Concentration:1 mg/mL

Immunogen:Recombinant Human TSPAN1 Protein

Buffer:0.2 μm filtered solution in PBS

Purification method:Protein A

Dilution:IHC-P 1:5000-1:20000;FCM 1:25-1:100;

Calculated MW:

ObservedMW: