Recombinant SHIP-2 Monoclonal Antibody

SKU: AN302029L

Size::50μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Monoclonal Antibodies;Recombinant Antibodies

Abbreviation:SHIP-2

Target Synonym:SHIP;INPPL;INPPL1;OPSMD;SHIP2;5 trisphosphate 5 phosphatase 2;51C protein;5-trisphosphate 5-phosphatase 2;EC 3.1.3.n1;inositol polyphosphate phosphatase like 1;Inositol polyphosphate phosphatase like protein 1;Inositol polyphosphate phosphatase-like protein 1;INPPL-1;Phosphatidylinositol 3;Protein 51C;SH2 domain containing inositol 5' phosphatase 2;SH2 domain-containing inositol 5''-phosphatase 2;SH2 domain-containing inositol phosphatase 2;SHIP-2

Research Areas:Cardiovascular;Signal Transduction;Immunology;Neuroscience

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human;

Application:WB;IHC;IF

Isotype:IgG,κ

Clonality:Monoclonal;Recombinant

Clone NO.:A749

UNIProt ID:O15357

Accession:

Background:SH2-containing inositol phosphatase 1 (SHIP1) is a hematopoietic phosphatase that hydrolyzes phosphatidylinositol-3,4,5-triphosphate to phosphatidylinositol-3,4-bisphosphate. SHIP1 is a cytosolic phosphatase with an SH2 domain in its amino terminus and two NPXY Shc binding motifs in its carboxy terminus. Upon receptor cross-linking, SHIP is first recruited to the membrane junction through binding of its SH2 domain to the phospho-tyrosine in the ITIM motif, followed by tyrosine phosphorylation on the NPXY motif. The membrane relocalization and phosphorylation on the NPXY motif is essential for the regulatory function of SHIP1. Its effect on calcium flux, cell survival, growth, cell cycle arrest, and apoptosis is mediated through the PI3K and Akt pathways. Tyr1021 is located in one of the NPXY motifs in SHIP1, and its phosphorylation is important for SHIP1 function.SHIP2, a homolog of SHIP1, is highly expressed in heart, skeletal muscle and placenta.SHIP2 negatively regulates insulin signaling and polymorphisms in SHIP2 have been linked to hyperglycemia. Recent studies also suggest SHIP2 as a therapeutic target for the treatment of both obesity and type 2 diabetes. Tyr1135 is phosphorylated in human cancer cells.

Concentration:1 mg/mL

Immunogen:Peptide. This information is proprietary to PTMab.

Buffer:PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Purification method:Protein A purified

Dilution:WB 1:1000;IHC 1:100;IF 1:50

Calculated MW:139 kDa

ObservedMW:140 kDa