Recombinant Shh Monoclonal Antibody

SKU: AN301249L

Size::50μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Recombinant Antibodies;Monoclonal Antibodies

Abbreviation:Shh

Target Synonym:HLP;HPE;MCOPCB;HHG1;HHG-1;HLP3;HPE3;MCOPCB5;SMMCI;Sonic hedgehog;Sonic Hedgehog Protein;TPT;TPTPS;SHH;HHG 1;HLP 3;Holoprosencephaly 3;HPE 3;SMMC I;Sonic Hedgehog (Drosophila) homolog;Sonic hedgehog homolog;sonic hedgehog homolog (Drosophila);Sonic hedgehog protein C-product;Shh

Research Areas:Epigenetics and Nuclear Signaling;Stem Cells;Cancer;Developmental Biology;Metabolism

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human;Mouse;Rat

Application:IHC

Isotype:IgG,κ

Clonality:Monoclonal;Recombinant

Clone NO.:2D9

UNIProt ID:Q15465

Accession:

Background:This gene encodes a protein that is instrumental in patterning the early embryo. It has been implicated as the key inductive signal in patterning of the ventral neural tube, the anterior-posterior limb axis, and the ventral somites. Of three human proteins showing sequence and functional similarity to the sonic hedgehog protein of Drosophila, this protein is the most similar. The protein is made as a precursor that is autocatalytically cleaved; the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing. More importantly, the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product, restricting the N-terminal product to the cell surface and preventing it from freely diffusing throughout the developing embryo.

Concentration:0.2 mg/mL

Immunogen:Recombinant Human Shh protein

Buffer:PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Purification method:Protein A

Dilution:IHC 1:200-1:1000

Calculated MW:

ObservedMW: