Recombinant Rhesus Macaque IL-8/CXCL8 protein

SKU: CD00032

Size:5 ug

Background:Interleukin-8 (IL-8) is encoded by the IL8 gene and produced by macrophages and other cell types such as epithelial cells. It is also synthesized by endothelial cells, which store IL-8 in their storage vesicles. There are many receptors capable to bind IL-8, the most affinity to IL-8 are receptors CXCR1, and CXCR2. As a member of the CXC chemokine family, function of IL-8 is the induction of chemotaxis in its target cells, like neutrophil granulocytes, basophils, and T-cells. Rhesus macaque IL-8 has approximately 94 % amino acid sequence identity with human IL-8.

Research_area:Immunology

Purity:> 95 % by SDS-PAGE and HPLC analyses.

Source:Escherichia coli.

Full product name:Recombinant Rhesus Macaque Interleukin-8

Biological activity:Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human CXCR2 transfected Mouse BaF3 cells is in a concentration range of .5-5. ng/ml.

Synonyms:IL-8/CXCL8, IL8,Monkey

Endotoxin:Less than 1 EU/μg of rRhIL-8/CXCL8 as determined by LAL method.

Storage:-20ºC

Sequence:AVLPRSAKEL RCECIKTYSK PFHPKFIKEL RVIESGPHCA NTEIIVKLSD GRELCLDPKE PWVQRVVEKF VKRAENQNP

uniprot accession:AA2K5EHB4

Molecular weight:Approximately 9.14kD containing 79 amino acid residues.

Formulation:

Reconstitution:Lyophilized from a .2 μm filtered concentrated solution in PBS, pH 7.4.