Recombinant Rat IP-10/CXCL10 protein

SKU: CD00096

Size:5 ug

Background:CXCL10 also known as IP-10 is belonging to the CXC chemokine family. It is encoded by the CXCL10 gene, and in rat it is also named the Mob-1 gene. This gene was identified on the basis of differential expression in rat embryo fibroblasts. CXCL10 elicits its effects by binding to the cell surface chemokine receptor CXCR3. CXCL10 has been shown to be a chemoattractant for activated T-lymphocytes and monocytes/macrophages. It also has other roles, such as promotion of T cell adhesion to endothelial cells, and inhibition of bone marrow colony formation and angiogenesis. Rat CXCL10 shares approximately 68 % amino acid sequence identity with human CXCL10.

Research_area:Immunology

Purity:> 95 % by SDS-PAGE and HPLC analyses.

Source:Escherichia coli.

Full product name:Recombinant Rat gamma-Interferon Inducible Protein 10/CXCL10

Biological activity:Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human CXCR3 transfected HEK293 cells is in a concentration range of 1-5 ng/ml.

Synonyms:IP-1/CXCL1, IP-1, Scyb1,Rat

Endotoxin:Less than 1 EU/μg of rRtIP-10/CXCL10 as determined by LAL method.

Storage:-20ºC

Sequence:IPLARTVRCT CIDFHEQPLR PRAIGKLEII PASLSCPHVE IIATMKKNNE KRCLNPESEA IKSLLKAVSQ RRSKRAP

uniprot accession:P48973

Molecular weight:Approximately 8.7 kDa, a single non-glycosylated polypeptide chain containing 77 amino acids.

Formulation:

Reconstitution:Lyophilized from a .2 μm filtered concentrated solution in PBS, pH 7.4.