Size:100ug. Other sizes are also available. Please contact us.
Research Areas:Immunology
Uniprot NO.:Q63086
Uniprot Entry Name:CTF1_RAT
Gene Names:Ctf1
Species:Rattus norvegicus (Rat)
Source:E.Coli
Expression Region:1-203aa
Sequence:MSQREGSLED HQTDSSFSFL PHLEAKIRQT HNLARLLTKY ADQLLEEYVQ QQGEPFGLPG FSPPRLPLAG LSGPAPSHAG LPVSERLRQD AAALSALPAL LDAVRRRQAE LNPRAPRLLR SLEDAARQVR ALGAAVETVL AALGAAARGP VPEPVATSAL FTSNSAAGVF SAKVLGLHVC GLYGEWVSRT EGDLGQLVPG GVA
Protein Description:Full Length
Tag Info:Tag-Free
Mol. Weight:21.4 kDa
Biological_Activity:Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using human TF-1 cells is less than 0.5 ng/ml, corresponding to a specific activity of ? 2.0 × 106 IU/mg.
Purity:>95% as determined by SDS-PAGE and HPLC.
Endotoxin:Less than 1.0 EU/µg as determined by LAL method.
Form:Lyophilized powder
Buffer:Lyophilized from a 0.2 µm filtered 20 mM PB, pH 7.4, 150mM NaCl
Reconstitution:We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20?/-80?. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Notes:Repeated freezing and thawing is not recommended. Store working aliquots at 4? for up to one week.
Alternative Name/ Alias:CT-1,
Relevance:Induces cardiac myocyte hypertrophy in vitro. Binds to and activates the ILST/gp130 receptor.
PubMed ID:8604995; 15489334
Function:Induces cardiac myocyte hypertrophy in vitro. Binds to and activates the ILST/gp130 receptor.
Involvement in disease:
Subcellular Location:Secreted
Protein Families:IL-6 superfamily
Tissue Specificity:Expressed in the ventricle and atrium of adult rats. Also detected in the lung, kidney, liver, skeletal muscle, stomach and urinary bladder. Not detected in brain, colon, testis, spleen or thymus. Overexpressed in the ventricles in the case of hypertension and hypertrophy.
Paythway:
HGNC Database Link:
UniGene Database Link:https://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Rn&CID=10253
KEGG Database Link:https://www.genome.jp/dbget-bin/www_bget?rno:29201
STRING Database Link:https://string-db.org/network/10116.ENSRNOP00000025646
OMIM Database Link: