Recombinant PTEN Monoclonal Antibody

SKU: AN301026L

Size::50μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Recombinant Antibodies;Monoclonal Antibodies

Abbreviation:PTEN

Target Synonym:CWS;GLM;TEP;MMAC;10q23del;BZS;CWS1;DEC;GLM2;MHAM;MMAC1;PTEN1;TEP1;PTEN;PTENbeta;5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN;MGC11227;MMAC1 phosphatase and tensin homolog deleted on chromosome 10;Mutated in multiple advanced cancers 1;Phosphatase and tensin homolog;Phosphatase and tensin like protein;Phosphatidylinositol 3;Phosphatidylinositol 3;4;5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

Research Areas:Cell Biology;Signal Transduction;Epigenetics and Nuclear Signaling;Cancer;Metabolism

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human;Mouse;Rat

Application:WB;IHC

Isotype:IgG,κ

Clonality:Monoclonal;Recombinant

Clone NO.:5A1

UNIProt ID:P60484

Accession:

Background:Phosphatase and tensin homolog(PTEN) Homo sapiens This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded by this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. The use of a non-canonical (CUG) upstream initiation site produces a longer isoform that initiates translation with a leucine, and is thought to be preferentially associated with the mitochondrial inner membrane.

Concentration:0.2 mg/mL

Immunogen:Recombinant Human PTEN protein

Buffer:PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Purification method:Protein A

Dilution:WB 1:1000-1:5000;IHC 1:200-1:1000

Calculated MW:47 kDa

ObservedMW:56 kDa