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Updated Date: Stock Protein updated on 20170405
Research areas: Others
Target / Protein: MDR1
Biologically active: Not Tested
Expression system: E.coli
Species of origin: Plasmodium falciparum (isolate FC27 / Papua New Guinea)
Delivery time: 3-7 business days
Uniprot ID: P13568
AA Sequence: KGDSENAKLSFEKYYPLMIRKSNIDVRDDGGIRINKNLIKGKVDIKDVNFRYISRPNVPIYKNLSFTCDSKKTTAIVGETGSGKSTFMNLLLRFYDLKNDHIILKNDMTNFQDYQNNNNNSLVLKNVNEFSNQSGSAEDYTVFNNNGEILLDDINICDYNLRDLRNLFSIVSQEPMLFNMSIYENIKFGREDATLEDVKRVSKFAAIDEFIESLPNKYDTNVGPYGKSLSGGQKQRIAIARALLREPKILLLDEATSSLDSNSEKLIEKTIVDIKDKADKTIITIAHRIASIKRSDKIVVFNNPDRNGTFVQSHGTHDELLSAQDGIYKKYVKLAK
Tag info: N-terminal 6xHis-SUMO-tagged
Expression Region: 1084-1419aa
Protein length: Cytoplasmic Domain
MW: 54.2 kDa
Alternative Name(s): Chloroquine resistance protein
Relevance: Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Reference: Amplification of the multidrug resistance gene in some chloroquine-resistant isolates of P. falciparum.Foote S.J., Thompson J.K., Cowman A.F., Kemp D.J.Cell 57:921-930(1989)
Purity: Greater than 90% as determined by SDS-PAGE.
Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20℃/-80℃. The shelf life of lyophilized form is 12 months at -20℃/-80℃.
Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.