Recombinant Phospho-Cyclin D1 (Thr286) Monoclonal Antibody

SKU: AN301503L

Size::50μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Monoclonal Antibodies;Recombinant Antibodies;Acetyl/Phospho/Methyl Antibodies

Abbreviation:Phospho-Cyclin D1 (Thr286)

Target Synonym:Cyl;PRAD;U21B;CCND;B cell leukemia;G1/S specific cyclin D;Cyclin D;BCL;BCL1;D11S287E;PRAD1;U21B31;CCND1;Cyclin D1;B cell leukemia 1;BCL 1;Cd1;Cyl 1;G1/S specific cyclin D1;BCL1;D11S287E;PRAD1;U21B31;CCND1;Cyclin D1;cyclin D1

Research Areas:Cell Biology;Epigenetics and Nuclear Signaling;Cancer

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human;Rat;Mouse

Application:WB;IHC;FCM

Isotype:IgG,κ

Clonality:Monoclonal;Recombinant

Clone NO.:A202

UNIProt ID:P24385

Accession:

Background:Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G1/S transition. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. Exhibits transcriptional corepressor activity with INSM1 on the NEUROD1 and INS promoters in a cell cycle-independent manner.

Concentration:1 mg/mL

Immunogen:Recombinant human Phospho-Cyclin D1 (Thr286) fragment

Buffer:PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Purification method:Protein A purified

Dilution:WB 1:500-1:2000;IHC 1:50-1:100;FCM 1:50

Calculated MW:34 kDa

ObservedMW:34 kDa