Recombinant PERK Monoclonal Antibody

SKU: AN301005L

Size::50μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Recombinant Antibodies;Monoclonal Antibodies

Abbreviation:PERK

Target Synonym:EIF2AK;EIF2AK3;PEK;PERK;WRS;DKFZp781H1925;E2AK3;EC 2.7.11.1;eukaryotic translation initiation factor 2 alpha kinase 3;Eukaryotic translation initiation factor 2-alpha kinase 3;Heme regulated EIF2 alpha kinase;HRI;HsPEK;Pancreatic eIF2 alpha kinase;Pancreatic eIF2-alpha kinase;PRKR like endoplasmic reticulum kinase;PRKR-like endoplasmic reticulum kinase

Research Areas:Epigenetics and Nuclear Signaling;Metabolism

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human;Mouse;Rat

Application:WB

Isotype:IgG,κ

Clonality:Monoclonal;Recombinant

Clone NO.:12B11

UNIProt ID:Q9NZJ5

Accession:

Background:The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2, leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. This protein is thought to modulate mitochondrial function. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome.

Concentration:0.2 mg/mL

Immunogen:Recombinant Human PERK protein

Buffer:PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Purification method:Protein A

Dilution:WB 1:1000-1:5000;

Calculated MW:125 kDa

ObservedMW:140 kDa