Recombinant Optineurin Monoclonal Antibody

SKU: AN301073L

Size::50μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Recombinant Antibodies;Monoclonal Antibodies

Abbreviation:Optineurin

Target Synonym:FIP;HIP;ALS;OPTN;ALS12;FIP2;GLC1E;HIP7;HYPL;NRP;TFIIIA-INTP;Optineurin;OPTN

Research Areas:Immunology;Signal Transduction;Neuroscience

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human;Mouse;Rat

Application:WB;IHC

Isotype:IgG,κ

Clonality:Monoclonal;Recombinant

Clone NO.:1F13

UNIProt ID:Q96CV9

Accession:

Background:This gene encodes the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14.7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins. Alternative splicing results in multiple transcript variants encoding the same protein.

Concentration:0.2 mg/mL

Immunogen:Recombinant Human Optineurin protein

Buffer:PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Purification method:Protein A

Dilution:IHC 1:200-500;WB 1:1000-5000

Calculated MW:63 kDa

ObservedMW:74 kDa