Recombinant MYPT1 Monoclonal Antibody

SKU: AN301350L

Size::

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Recombinant Antibodies;Monoclonal Antibodies

Abbreviation:MYPT1

Target Synonym:MYPT;PPP1R12A;M130;MBS;MYPT1;Myosin binding subunit;Myosin phosphatase target subunit 1;Myosin phosphatase targeting subunit 1;Myosin phosphatase-targeting subunit 1;Protein phosphatase 1;Protein phosphatase 1 regulatory inhibitor subunit 12A;Protein phosphatase 1 regulatory subunit 12A;Protein phosphatase myosin binding subunit;Protein phosphatase myosin-binding subunit;regulatory (inhibitor) subunit 12A

Research Areas:Signal Transduction;Epigenetics and Nuclear Signaling

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human

Application:WB

Isotype:IgG,κ

Clonality:Monoclonal;Recombinant

Clone NO.:7A12

UNIProt ID:O14974

Accession:

Background:Myosin phosphatase target subunit 1, which is also called the myosin-binding subunit of myosin phosphatase, is one of the subunits of myosin phosphatase. Myosin phosphatase regulates the interaction of actin and myosin downstream of the guanosine triphosphatase Rho. The small guanosine triphosphatase Rho is implicated in myosin light chain (MLC) phosphorylation, which results in contraction of smooth muscle and interaction of actin and myosin in nonmuscle cells. The guanosine triphosphate (GTP)-bound, active form of RhoA (GTP.RhoA) specifically interacted with the myosin-binding subunit (MBS) of myosin phosphatase, which regulates the extent of phosphorylation of MLC. Rho-associated kinase (Rho-kinase), which is activated by GTP. RhoA, phosphorylated MBS and consequently inactivated myosin phosphatase.

Concentration:0.2 mg/mL

Immunogen:Recombinant Human MYPT1 protein

Buffer:PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Purification method:Protein A

Dilution:WB 1:2000-1:10000

Calculated MW:140 kDa

ObservedMW:140 kDa