Recombinant MYH7 Monoclonal Antibody

SKU: AN301987L

Size::50μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Monoclonal Antibodies;Recombinant Antibodies

Abbreviation:MYH7

Target Synonym:CMH;MPD;MYH;myosin;MYH7;CMD1S;CMH1;MPD1;MYHCB;SPMD;SPMM;myosin-7;PVALB

Research Areas:Signal Transduction;Stem Cells;Cardiovascular;Developmental Biology;Immunology

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human;Rat;Mouse

Application:IHC

Isotype:IgG,κ

Clonality:Monoclonal;Recombinant

Clone NO.:A707

UNIProt ID:P12883

Accession:

Background:Nonmuscle myosin is an actin-based motor protein essential to cell motility, cell division, migration, adhesion, and polarity. The holoenzyme consists of two identical heavy chains and two sets of light chains. The light chains (MLCs) regulate myosin II activity and stability. The heavy chains (NMHCs) are encoded by three genes, MYH9, MYH10, and MYH14, which generate three different nonmuscle myosin II isoforms, IIa,IIb, and IIc, respectively. While all three isoforms perform the same enzymatic tasks, binding to and contracting actin filaments coupled to ATPhydrolysis, their cellular functions do not appear to be redundant and they have different subcellular distributions. The carboxy-terminal taildomain of myosin II is important in isoform-specific subcellular localization. Research studies have shown that phosphorylation of myosin IIa at Ser1943 contributes to the regulation of breast cancer cell migration.

Concentration:1 mg/mL

Immunogen:Peptide. This information is proprietary to PTMab.

Buffer:PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Purification method:Protein A purified

Dilution:IHC 1:1000-1:2000

Calculated MW:

ObservedMW: