Recombinant Mouse MIP-1 Alpha/CCL3 protein

SKU: CD00298

Size:2 ug

Background:CCL3, also known as macrophage inflammatory protein-1α (MIP-1α), is a cytokine belonging to the CC chemokine family that is involved in the acute inflammatory state in the recruitment and activation of polymorphonuclear leukocytes. Studies showed CCL3 can bind to CCR1, CCR4 and CCR5. MIP-1α can induce a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). Recombinant Mouse MIP-1α is a 7.9 kDa protein containing 69 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines and it shares approximately 71 % and 91 % amino acid sequence homology with the human and rat protein.

Research_area:Others

Purity:> 98 % by SDS-PAGE and HPLC analyses.

Source:Escherichia coli.

Full product name:Recombinant Mouse Macrophage Inflammatory Protein-1 alpha/CCL3

Biological activity:Fully biologically active when compared to standard. The biological activity determined by a chemoattract bioassay using Mouse splenocytes is in a concentration range of 1-1 ng/ml.

Synonyms:MIP-1α/CCL3,AI32384, CCL, GS19-, GS19-1, LD78, LD78alpha, MIP-, MIP-1alpha, MIP1, MIP1-, MIP1-(a), MIP1-alpha, Mi, Mip1a, Scy, Scya3, Mouse

Endotoxin:Less than 0.1 EU/μg of rMuMIP-1α/CCL3 as determined by LAL method.

Storage:-20ºC

Sequence:APYGADTPTA CCFSYSRKIP RQFIVDYFET SSLCSQPGVI FLTKRNRQIC ADSKETWVQE YITDLELNA

uniprot accession:P1855

Molecular weight:Approximately 7.9 kDa protein containing 69 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines.

Formulation:

Reconstitution:Lyophilized from a .2 μm filtered concentrated solution in 3 % Acetonitrile and .1 % TFA.