Recombinant Mouse IP-10/CXCL10 protein

SKU: CD00331

Size:5 ug

Background:CXCL10 also known as IP-10 is belonging to the CXC chemokine family. It is encoded by the CXCL10 gene, and in Mouse it is also named the CRG-2 gene. The gene was originally identified as an immediate early gene induced in response to macrophage activation. This chemokine elicits its effects by binding to the cell surface chemokine receptor CXCR3. CXCL10 has been shown to be a chemoattractant for activated T-lymphocytes and monocytes/macrophages. It also has other roles, such as promotion of T cell adhesion to endothelial cells, and inhibition of bone marrow colony formation and angiogenesis. Mouse CXCL10 shares approximately 67 % amino acid sequence identity with human CXCL10.

Research_area:Immunology

Purity:> 97 % by SDS-PAGE and HPLC analyses.

Source:Escherichia coli.

Full product name:Recombinant Mouseγ-Interferon Inducible Protein 10/CXCL10

Biological activity:Fully biologically active when compared to standard. The biologically active determined by a chemotaxis bioassay using human peripheral blood lymphocytes is in a concentration range of .1-1. ng/ml in the presence of IL-2.

Synonyms:IP-1/CXCL1,C7, CRG-, CRG-2, IN, INP1, IP, IP-, IP-1, IP1, Ifi, Ifi1, Scyb1, Scyb1, gIP-, gIP-1, mob-, mob-1, Mouse

Endotoxin:Less than 1 EU/μg of rMuIP-10/CXCL10 as determined by LAL method.

Storage:-20ºC

Sequence:IPLARTVRCN CIHIDDGPVR MRAIGKLEII PASLSCPRVE IIATMKKNDE QRCLNPESKT IKNLMKAFSQ KRSKRAP

uniprot accession:P17515

Molecular weight:Approximately 8.7 kDa, a single non-glycosylated polypeptide chain containing 77 amino acids.

Formulation:

Reconstitution:Lyophilized from a .2 μm filtered concentrated solution in 2 × PBS, pH 7.4.