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Updated Date: Stock Protein updated on 20170725
Research areas: Immunology
Target / Protein: Jchain
Biologically active: Not Tested
Expression system: E.coli
Species of origin: Mus musculus (Mouse)
Delivery time: 3-7 business days
Uniprot ID: P01592
AA Sequence: GDDEATILADNKCMCTRVTSRIIPSTEDPNEDIVERNIRIVVPLNNRENISDPTSPLRRNFVYHLSDVCKKCDPVEVELEDQVVTATQSNICNEDDGVPETCYMYDRNKCYTTMVPLRYHGETKMVQAALTPDSCYPD
Tag info: N-terminal 6xHis-SUMO-tagged
Expression Region: 22-159aa
Protein length: Full Length of Mature Protein
MW: 31.7 kDa
Alternative Name(s): Igj
Relevance: Serves to link two monomer units of either IgM or IgA. In the case of IgM, the J chain-joined dimer is a nucleating unit for the IgM pentamer, and in the case of IgA it induces larger polymers. It also help to bind these immunoglobulins to secretory component.
Reference: "Lack of J chain inhibits the transport of gut IgA and abrogates the development of intestinal antitoxic protection." Lycke N., Erlandsson L., Ekman L., Schon K., Leanderson T. J. Immunol. 163:913-919(1999)
Purity: Greater than 90% as determined by SDS-PAGE.
Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20℃/-80℃. The shelf life of lyophilized form is 12 months at -20℃/-80℃.
Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.