Recombinant Mouse IL-28B protein(His Tag)

SKU: PKSM041474

Size: 100μg

Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Shipping: This product is provided as lyophilized powder which is shipped with ice packs.

Exp date: 12 months

Category ID_II: Recombinant Proteins

Category ID_III: Cytokines

Abbreviation: IL-28B

Target Synonym: Cytokine Zcyto;IL-12 subunit p;ZCYTO;Cytokine Zcyto22;Cytotoxic Lymphocyte Maturation Factor 35 kDa;IFNL4;IFN-Lambda-3;IFN-Lambda-4;IL-12 subunit p35;IL-12A;IL-28B;IL28C;IL-28C;Interferon Lambda-3;Interferon Lambda-4;Interleukin-12 subunit alpha;Interleukin-28B;Interleukin-28C;ZCYTO22;Il28;Il28b;Ifnl3

Research Areas:

Conjugation:

Target Species: Mouse

Expression Host: E.coli

Application: Cell culture

Fusion tag: C-His

UNIProt ID: Q8CGK6

Accession: Q8CGK6

Background: Interleukin-28B; also known as Cytokine Zcyto22; Interferon lambda-3; Interferon lambda-4; IFNL3; IFNL4; ZCYTO22 and IL28B; is a secreted cytokine which belongs to the IL-28/IL-29 family. IL-28 has also been shown to play a role in the adaptive immune response. IL28B has immunomodulatory activity and up-regulates MHC class I antigen expression. IL28B displays potent antiviral activity and antitumor activity. In addition; IL28B is a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IL28RA. The ligand/receptor complex seems to signal through the Jak-STAT pathway.

Concentration:

Activity: Measure by its ability to protect HepG2 cells infected with encephalomyocarditis (EMC) virus.The ED₅₀ for this effect is <20 ng/mL.

Sequence: Asp 20-Val 193

Purity: > 98 % as determined by reducing SDS-PAGE.

Formulation: Lyophilized from sterile PBS, pH 7.4.
Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.

Reconstitution: Please refer to the printed manual for detailed information.

Endotoxin: < 0.1 EU per μg of the protein as determined by the LAL method.

Calculated MW: 20.6 kDa

ObservedMW: 17-25 kDa