Recombinant Mouse CTACK/CCL27 protein

SKU: CD00504

Size:5 ug

Background:CCL27, also named IL-11 R-alpha-locus chemokine (ILC), skinkine, eskine and cutaneous T-cell-attracting chemokine (CTACK), is a small cytokine belonging to the CC chemokine family. CCL27 is expressed in numerous tissues, including gonads, thymus, placenta and skin and it elicits its chemotactic effects by binding to the chemokine receptor CCR10. CCL27 can attract skin-associated memory T-lymphocytes. Studies showed it may play a role in mediating homing of lymphocytes to cutaneous sites and cell migration during embryogenesis. Mature mouse CCL27 is a 95 amino acid (a.a.) protein that shares 57 % a.a. and 87 % a.a. sequence identity with human and rat CCL27, respectively. It shares 18 %~31 % a.a. sequence identity with other mouse CC chemokines.

Research_area:Immunology

Purity:> 98 % by SDS-PAGE and HPLC analyses.

Source:Escherichia coli.

Full product name:Recombinant Mouse Cuteaneous T-cell Attracting Chemokine/CCL27

Biological activity:Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human peripheral blood lymphocytes is in a concentration range of 1-1 ng/ml.

Synonyms:CTACK/CCL27,mI; ALP; CTA; ESk; ILC; PES; ski; CTAC; CTAK; Ccl2; Scya; CTACK; Ccl27; PESKY; ESkine; Scya27; Scya27a; AW558992, Mouse

Endotoxin:Less than 1 EU/μg of rMuCTACK/CCL27 as determined by LAL method.

Storage:-20ºC

Sequence:LPLPSSTSCC TQLYRQPLPS RLLRRIVHME LQEADGDCHL QAVVLHLARR SVCVHPQNRS LARWLERQGK RLQGTVPSLN LVLQKKMYSN PQQQN

uniprot accession:Q9Z1X

Molecular weight:Approximately 1.9 kDa, a single, non-glycosylated polypeptide chain containing 95 amino acids.

Formulation:

Reconstitution:Lyophilized from a .2 μm filtered concentrated solution in 2 × PBS, pH 7.4, with 5% trehalose.