Recombinant Mouse CEACAM-1/CD66a Protein(Fc Tag)

SKU: PDMM100147

Size:100μg

Storage:Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Shipping:This product is provided as lyophilized powder which is shipped with ice packs.

Exp date:12 months

Category ID_II:Recombinant Proteins

Category ID_III:Immune Checkpoint Proteins

Abbreviation:CEACAM-1/CD66a

Target Synonym:Antigen CD;meconium antigen;Biliary glycoprotein;Carcinoembryonic antigen-related cell adhesion molecule;MHVR;CEACAM;Antigen CD66;BGP 1;Biliary glycoprotein 1;Biliary glycoprotein D;Carcinoembryonic antigen-related cell adhesion molecule 1;CD66a;meconium antigen 100;MHV-R;MHVR1;Murine hepatitis virus receptor;Bgp;Bgp1;Ceacam1;CEACAM-1; CEACAM-2; BGP; CEA-1;bb-1;BGP-1;BGPI;Biliary glycoprotein adhesion molecule;Carcinoembryonic antigen related cell adhesion molecule 1;carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein);Cc1;C-CAM;CD66a antigen;Cea1;Cea-1;Cea7;Cea-7;CEAM1;Hv2;Hv-2;mCEA1;Mhv-1;mmCGM1;mmCGM1a;mmCGM2

Research Areas:

Conjugation:

Target Species:Mouse

Expression Host:Mammalian

Application:

Fusion tag:C-Fc

UNIProt ID:P31809

Accession:P31809

Background:The carcinoembryonic-antigen-related cell-adhesion molecule (CEACAM) family of proteins has been implicated in various intercellular-adhesion and intracellular-signalling-mediated effects that govern the growth and differentiation of normal and cancerous cells. CEACAM1 , also known as biliary glycoprotein I (BGP I) and CD66a , is a member of the carcinoembryonic antigen (CEA) gene family which belongs to the immunoglobulin superfamily. The highly glycosylated CEACAM1 contains one N-terminal V-type Ig-like domain and three C2-type Ig-like domains within its ECD , and one ITIM motif and a calmodulin binding site in the cytoplasmic region. CEACAM1 is a surface glycoprotein expressed on various blood cells , epithelial cells , and vascular cells. It was described as an adhesion molecule mediating cell adhesion via both homophilic and heterophilic manners , and was detected on leukocytes , epithelia , and endothelia. Studies have revealed that CEACAM1 performs actions in multiple cellular processes including tissue differentiation , angiogenesis , apoptosis , metastasis , as well as the modulation of innate and adaptive immune responses.

Concentration:

Activity:Not validated for activity

Sequence:Glu35-Gly428

Purity: > 90% as determined by reducing SDS-PAGE.

Formulation:Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol.

Reconstitution:It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.

Endotoxin:< 1.0 EU/mg of the protein as determined by the LAL method.

Calculated MW:68.2 kDa

ObservedMW:90 kDa