Recombinant Mouse Cardiotrophin-1 protein(Ctf1) (Active)

CSB-AP000531MO

Size:100ug. Other sizes are also available. Please contact us.

Research Areas:Immunology

Uniprot NO.:Q60753

Uniprot Entry Name:CTF1_MOUSE

Gene Names:Ctf1

Species:Mus musculus (Mouse)

Source:E.Coli

Expression Region:1-203aa

Sequence:MSQREGSLED HQTDSSISFL PHLEAKIRQT HNLARLLTKY AEQLLEEYVQ QQGEPFGLPG FSPPRLPLAG LSGPAPSHAG LPVSERLRQD AAALSVLPAL LDAVRRRQAE LNPRAPRLLR SLEDAARQVR ALGAAVETVL AALGAAARGP GPEPVTVATL FTANSTAGIF SAKVLGFHVC GLYGEWVSRT EGDLGQLVPG GVA

Protein Description:Full Length

Tag Info:Tag-Free

Mol. Weight:21.5 kDa

Biological_Activity:Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using human TF­1 cells is less than 0.5 ng/ml, corresponding to a specific activity of ? 2.0 × 106 IU/mg.

Purity:>95% as determined by SDS­PAGE and HPLC.

Endotoxin:Less than 1.0 EU/µg as determined by LAL method.

Form:Lyophilized powder

Buffer:Lyophilized from a 0.2 µm filtered 20 mM PB, pH 7.4, 150mM NaCl

Reconstitution:We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20?/-80?. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Notes:Repeated freezing and thawing is not recommended. Store working aliquots at 4? for up to one week.

Alternative Name/ Alias:CT-1,

Relevance:Induces cardiac myocyte hypertrophy in vitro. Binds to and activates the ILST/gp130 receptor.

PubMed ID:7862649; 15489334

Function:Induces cardiac myocyte hypertrophy in vitro. Binds to and activates the ILST/gp130 receptor.

Involvement in disease:

Subcellular Location:Secreted

Protein Families:IL-6 superfamily

Tissue Specificity:Highly expressed in heart, skeletal muscle, liver, lung and kidney. Lower levels in testis and brain. No expression in spleen.

Paythway:

HGNC Database Link:

UniGene Database Link:https://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Mm&CID=389954

KEGG Database Link:https://www.genome.jp/dbget-bin/www_bget?mmu:13019

STRING Database Link:https://string-db.org/network/10090.ENSMUSP00000049161

OMIM Database Link: