Recombinant Mouse C10/CCL6 protein

SKU: CD00604

Size:2 ug

Background:Chemokine (C-C motif) ligand 6 (CCL6), encoded by the gene CCL6, is a small cytokine belonging to the CC chemokine family that has only been identified in rodents. Mouse CCL6 is expressed in myelopoietic bone marrow cultures when stimulated with GM-CSF, M-CSF, IL-3 or IL-4 and has also been detected in an IL-2-dependent T cell line, where the expression is inhibited following T cell stimulation. It signals primarily through the CCR1 receptor. CCL6 is chemotactic for B cells, CD4+ T cells, monocytes and NK cells and also exhibits powerful suppressive activity on colony formation by different lineages of hematopoietic progenitors. The C10 contains the four highly conserved cysteine residues present in CC chemokines.

Research_area:Immunology

Purity:> 97 % by SDS-PAGE and HPLC analyses.

Source:Escherichia coli.

Full product name:Recombinant Mouse Protein C10/CCL6

Biological activity:Fully biologically active when compared to standard. The biologically active determined by a chemotaxis bioassay using human CCR1 transfected Mouse BaF3 cells is in a concentration range of 1-1 ng/ml.

Synonyms:C1/CCL6,MRP, MRP-1, Scy, Scya6, c1, Mouse

Endotoxin:Less than 1 EU/μg of rMuC10/CCL6 as determined by LAL method.

Storage:-20ºC

Sequence:GLIQEIEKED RRYNPPIIHQ GFQDTSSDCC FSYATQIPCK RFIYYFPTSG GCIKPGIIFI SRRGTQVCAD PSDRRVQRCL STLKQGPRSG NKVIA

uniprot accession:P27784

Molecular weight:Approximately 1.7 kDa, a single non-glycosylated polypeptide chain containing 95 amino acids.

Formulation:

Reconstitution:Lyophilized from a .2 μm filtered concentrated solution in 2 mM Tris, pH 8., 5 mM NaCl.