Recombinant HVEM/TNFRSF14/CD270 Monoclonal Antibody

SKU: AN300320P

Size::

Storage:This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Recombinant Antibodies;Monoclonal Antibodies

Abbreviation:TNFRSF14

Target Synonym:UNQ;PRO;Tumor Necrosis Factor Receptor-Like;Tumor Necrosis Factor Receptor Superfamily Member;Tnfrsf;CD270;Herpes Virus Entry Mediator A;Herpesvirus Entry Mediator A;TR2;Tumor Necrosis Factor Receptor Superfamily Member 14;Tumor Necrosis Factor Receptor-Like 2;HVEA;HVEM;TNFRSF14;UNQ329;PRO509

Research Areas:Immunology;Signal Transduction;Cancer

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human

Application:ICC/IF

Isotype:IgG

Clonality:Monoclonal

Clone NO.:8D9

UNIProt ID:Q92956

Accession:

Background:Herpesvirus entry mediator (HVEM), also referred to as TNFRSF14, TR2 (TNF receptor-like molecule) and ATAR (another TRAF-associated receptor), is a member of type I transmembrane protein belonging to the TNF-receptor superfamily. It is expressed on many immune cells, including T and B cells, NK cells, monocytes, and neutrophils. Two TNF superfamily ligands lymphotoxin α (TNF-β) and LIGHT (TNFSF14) are identified as cellular ligands for HVEM and initiate the positive signaling. However, recent studies have revealed that HVEM is also involved in the unique inhibitory signaling pathway for T cells through activating tyrosine phosphorylation of the immunoreceptor tyrosine-based inhibitory motif (ITIM) in B and T lymphocyte attenuator (BTLA). HVEM provides a stimulatory signal following engagement with LIGHT (TNFSF14) on T cells. In contrast, it can also provide an inhibitory signal to T cells when it binds the B and T lymphocyte attenuator (BTLA), a ligand member of the Immunoglobulin (Ig) superfamily. Thus, HVEM may be viewed as a molecular switch, capable of facilitating both stimulatory and inhibitory cosignaling in T cells. Substantial evidence from both human disease and from experimental mouse models has indicated that dysregulation of the LIGHT-HVEM-BTLA cosignaling pathway can cause inflammation in the lung and in mucosal tissues.

Concentration:1 mg/mL

Immunogen:Recombinant Human HVEM/TNFRSF14/CD270 Protein

Buffer:0.2 μm filtered solution in PBS

Purification method:Protein A

Dilution:ICC/IF 1:20-1:100

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ObservedMW: