Size:100ug. Other sizes are also available. Please contact us.
Research Areas:Immunology
Uniprot NO.:P11684
Uniprot Entry Name:UTER_HUMAN
Gene Names:SCGB1A1,CC10,CCSP,UGB
Species:Homo sapiens (Human)
Source:E.Coli
Expression Region:22-91aa
Sequence:EICPSFQRVI ETLLMDTPSS YEAAMELFSP DQDMREAGAQ LKKLVDTLPQ KPRESIIKLM EKIAQSSLCN
Protein Description:Full Length of Mature Protein
Tag Info:Tag-Free
Mol. Weight:7.9 kDa
Biological_Activity:Fully biologically active when compared to standard. The ED50 as determined by the ability of the immobilized protein to support the adhesion of the A549 human lung carcinoma cells is less than 5.0 ?g/ml, corresponding to a specific activity of ? 200 IU/m.
Purity:>98% as determined by SDS-PAGE and HPLC.
Endotoxin:Less than 1.0 EU/µg as determined by LAL method.
Form:Lyophilized powder
Buffer:Lyophilized from a 0.2 µm filtered concentrated solution in PBS, pH 7.4.
Reconstitution:We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20?/-80?. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Notes:Repeated freezing and thawing is not recommended. Store working aliquots at 4? for up to one week.
Alternative Name/ Alias:Clara cell phospholipid-binding protein, Clara cells 10 kDa secretory protein, CC10, Secretoglobin family 1A member 1, Urinary protein 1
Relevance:Binds phosphatidylcholine, phosphatidylinositol, polychlorinated biphenyls (PCB) and weakly progesterone, potent inhibitor of phospholipase A2.
PubMed ID:3167058; 7733299; 14702039; 15489334; 1284526; 1400743; 1395029; 11788998; 7664082
Function:Binds phosphatidylcholine, phosphatidylinositol, polychlorinated biphenyls (PCB) and weakly progesterone, potent inhibitor of phospholipase A2.
Involvement in disease:
Subcellular Location:Secreted
Protein Families:Secretoglobin family
Tissue Specificity:Clara cells (nonciliated cells of the surface epithelium of the pulmonary airways).
Paythway:
HGNC Database Link:https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=HGNC:12523
UniGene Database Link:https://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Hs&CID=523732
KEGG Database Link:https://www.genome.jp/dbget-bin/www_bget?hsa:7356
STRING Database Link:https://string-db.org/network/9606.ENSP00000278282
OMIM Database Link:https://www.omim.org/entry/192020192020192020