Recombinant Human ST6GAL1 Protein (His Tag)

SKU: PKSH033362

Size: 50μg

Storage: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.

Exp date: 12 months

Category ID_II: Recombinant Proteins

Category ID_III: Others

Abbreviation: ST6GAL1

Target Synonym: 6-ST 1;6-Sialyltransferase 1;Alpha 2;B-Cell Antigen CD75;Beta-Galactoside Alpha-2;CMP-N-Acetylneuraminate-Beta-Galactosamide-Alpha-2;SIAT1;ST6GAL1;ST6Gal I;ST6GalI;Sialyltransferase 1

Research Areas: Signal Transduction;immunology;

Conjugation:

Target Species: Human

Expression Host: HEK293 Cells

Application:

Fusion tag: C-His

UNIProt ID: P15907

Accession: P15907

Background: The ST6GAL1 gene encodes β-Galactosamide α-2;6-Sialyltransferase 1. It is a type II membrane protein and is localized to the trans-Golgi network. It catalyzes 2;6-sialylation of Galβ1;4-GlcNAc structures on N-glycans. ST6GAL1 is highly expressed in the liver and other tissues. ST6GAL1 deficiency causes abnormalities in B-cell immunoreactivity. The expression and activity of ST6GAL1 are associated with tumor metastasis in breast and colon cancers. The majority of ST6GAL1 in the liver is cleaved and secreted into the serum and may be used as a biomarker for hepatitis diseases.

Concentration:

Activity: Not validated for activity

Sequence: Lys27-Cys406

Purity: > 95 % as determined by reducing SDS-PAGE.

Formulation: Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, pH 8.0.

Reconstitution: Not Applicable

Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.

Calculated MW: 44.6 kDa

ObservedMW: 41-60 kDa