Size:100ug. Other sizes are also available. Please contact us.
Research Areas:Immunology
Uniprot NO.:P48745
Uniprot Entry Name:NOV_HUMAN
Gene Names:NOV,CCN3,IGFBP9,NOVH
Species:Homo sapiens (Human)
Source:E.Coli
Expression Region:28-357aa
Sequence:M+QVAATQRCP PQCPGRCPAT PPTCAPGVRA VLDGCSCCLV CARQRGESCS DLEPCDESSG LYCDRSADPS NQTGICTAVE GDNCVFDGVI YRSGEKFQPS CKFQCTCRDG QIGCVPRCQL DVLLPEPNCP APRKVEVPGE CCEKWICGPD EEDSLGGLTL AAYRPEATLG VEVSDSSVNC IEQTTEWTAC SKSCGMGFST RVTNRNRQCE MLKQTRLCMV RPCEQEPEQP TDKKGKKCLR TKKSLKAIHL QFKNCTSLHT YKPRFCGVCS DGRCCTPHNT KTIQAEFQCS PGQIVKKPVM VIGTCTCHTN CPKNNEAFLQ ELELKTTRGK M
Protein Description:Full Length of Mature Protein
Tag Info:Tag-Free
Mol. Weight:36.2 kDa
Biological_Activity:Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using murine Balb/c 3T3 cells is less than 1.0 ?g/ml, corresponding to a specific activity of ? 1000 IU/mg.
Purity:>95% as determined by SDS-PAGE and HPLC.
Endotoxin:Less than 1.0 EU/µg as determined by LAL method.
Form:Lyophilized powder
Buffer:Lyophilized from a 0.2 µm filtered PBS, pH 7.0
Reconstitution:We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20?/-80?. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Notes:Repeated freezing and thawing is not recommended. Store working aliquots at 4? for up to one week.
Alternative Name/ Alias:NovH, Insulin-like growth factor-binding protein 9, IBP-9, IGF-binding protein 9, IGFBP-9
Relevance:Immediate-early protein likely to play a role in cell growth regulation. {ECO:0000250}.
PubMed ID:7520150; 8622864; 14702039; 15489334; 1756408; 15340161; 9927660
Function:Immediate-early protein playing a role in various cellular processes including proliferation, adhesion, migration, differentiation and survival
Involvement in disease:
Subcellular Location:Secreted, Cytoplasm, Cell junction, gap junction
Protein Families:CCN family
Tissue Specificity:Expressed in endiothelial cells (at protein level) (PubMed:21063504). Expressed in bone marrow, thymic cells and nephroblastoma. Increased expression in Wilms tumor of the stromal type.
Paythway:
HGNC Database Link:https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=HGNC:7885
UniGene Database Link:https://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Hs&CID=235935
KEGG Database Link:https://www.genome.jp/dbget-bin/www_bget?hsa:4856
STRING Database Link:https://string-db.org/network/9606.ENSP00000259526
OMIM Database Link:https://www.omim.org/entry/164958164958164958