Recombinant Human PLA2G7/Lp-PLA2 Protein (His Tag)

SKU: PKSH033398

Size: 50μg

Storage: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.

Exp date: 12 months

Category ID_II: Recombinant Proteins

Category ID_III: Others

Abbreviation: PLA2G7;Lp-PLA2

Target Synonym: 1-alkyl-2-acetylglycerophosphocholine esterase;2-acetyl-1-alkylglycerophosphocholine esterase;EC 3.1.1;EC 3.1.1.47;Group-VIIA phospholipase A2;LDL-PLA(2);LDL-PLA2;LDL-associated phospholipase A2;Lp;LpPLA2;gVIIA-PLA2;lipoprotein-associated phospholipase A2

Research Areas: Immunology,Cardiovascular

Conjugation:

Target Species: Human

Expression Host: HEK293 Cells

Application:

Fusion tag: C-His

UNIProt ID: Q13093

Accession: AAH38452.1

Background: Platelet-Activating Factor Acetylhydrolase (PAFAH) is a secreted enzyme which belongs to the AB hydrolase superfamily and Lipase family and catalyzes the degradation of platelet-activating factor to biologically inactive products. PAFAH is produced by inflammatory cells and hydrolyzes oxidised phospholipids in LDL. PAFAH has been implicated in the development of atherosclerosis and has also been identified as a marker for cardiac disease. PAFAH might have a major physiologic effect in the presence of inflammatory bodily responses. PAFAH alters the action of PAF by hydrolyzing the sn-2 ester bond to yield the biologically inactive lyso-PAF. PAFAH has specificity for substrates with a short residue at the sn-2 position.

Concentration:

Activity: Not validated for activity

Sequence: Phe22-Asn441

Purity: > 90 % as determined by reducing SDS-PAGE.

Formulation: Supplied as a 0.2 μm filtered solution of 50mM NaAc, 150mM NaCl, 50% Glycerol, pH5.0.

Reconstitution: Not Applicable

Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.

Calculated MW: 48.8 kDa

ObservedMW: 50-65 kDa