Recombinant Human PADI4 Protein (His Tag)

SKU: PKSH032973

Size: 50μg

Storage: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.

Exp date: 12 months

Category ID_II: Recombinant Proteins

Category ID_III: Others

Abbreviation: PADI4

Target Synonym: HL-60 PAD;PADI4;PADI5;PDI5;Peptidylarginine Deiminase IV;Protein-Arginine Deiminase Type-4;Protein-arginine Deiminase type IV

Research Areas: Signal Transduction;epigenetics and nuclear signal;metabolism;

Conjugation:

Target Species: Human

Expression Host: E.coli

Application:

Fusion tag: N-His

UNIProt ID: Q9UM07

Accession: AAH25718.1

Background: Protein-Arginine Deiminase Type-4 (PADI4) belongs to the Protein Arginine Deiminase family. PADI4 is expressed in eosinophils and neutrophils, but it is not expressed in peripheral monocytes or lymphocytes. PADI4 catalyzes the citrullination/deimination of arginine residues of proteins. In addition, PADI4 may play an important role in tumourigenesis. Genetic variations in PADI4 are a cause of susceptibility to rheumatoid arthritis (RA), which is a systemic inflammatory disease with autoimmune features and a complex genetic component.

Concentration:

Activity: Not validated for activity

Sequence: Met 1-Pro663

Purity: > 95 % as determined by reducing SDS-PAGE.

Formulation: Supplied as a 0.2 μm filtered solution of 50mM Tris-HCl, 500mM NaCl, pH 7.5.

Reconstitution: Not Applicable

Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.

Calculated MW: 76.2 kDa

ObservedMW: 78 kDa