Recombinant Human IL2RG/CD132 Protein (aa 1-254, Fc Tag)

SKU: PKSH031531

Size: 100μg

Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Shipping: This product is provided as lyophilized powder which is shipped with ice packs.

Exp date: 12 months

Category ID_II: Recombinant Proteins

Category ID_III: Others

Abbreviation: IL2RG/CD132

Target Synonym: IMD;IL2RG;CD132;CIDX;IL-2RG;IMD4;P64;SCIDX;SCIDX1;Cytokine receptor common subunit gamma;gammaC;Interleukin-2 receptor subunit gamma;common &gamma- chain-n; IL-2R&gamma

Research Areas: Cancer;immunology

Conjugation:

Target Species: Human

Expression Host: HEK293 Cells

Application:

Fusion tag: C-hFc

UNIProt ID: P31785

Accession: P31785

Background: The common gamma chain (γc) (or CD132); also known as interleukin-2 receptor subunit gamma or IL2RG; is a member of the type I cytokine receptor family expressed on most lymphocyte (white blood cell) populations; and its gene is found on the X-chromosome of mammals. The common gamma chain (γc) (or IL2RG); is a cytokine receptor sub-unit that is common to the receptor complexes for at least six different interleukin receptors: IL-2; IL-4; IL-7; IL-9; IL-15 and interleukin-21 receptor. It is a component of multiple cytokine receptors that are essential for lymphocyte development and function. X-linked severe combined immunodeficiency (XSCID) is a rare and potentially fatal disease caused by mutations of IL2RG; the gene encoding IL2RG. IL2RG was demonstrated to be a component of the IL-4 receptor on the basis of chemical cross-linking data; the ability of IL2RG to augment IL-4 binding affinity. The observation that IL-2R gamma is a functional component of the IL-4 receptor; together with the finding that IL-2R gamma associates with the IL-7 receptor; begins to elucidate why deficiency of this common gamma chain (gamma c) has a profound effect on lymphoid function and development; as seen in X-linked severe combined immunodeficiency.

Concentration:

Activity: Not validated for activity

Sequence: Met 1-Asn254

Purity: > 99 % as determined by reducing SDS-PAGE.

Formulation: Lyophilized from sterile PBS, pH 7.4
Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.

Reconstitution: Please refer to the printed manual for detailed information.

Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.

Calculated MW: 54.4 kDa

ObservedMW: 71 kDa